Calcium Regulates S100A12 Zinc Sequestration by Limiting Structural Variations
نویسندگان
چکیده
منابع مشابه
Calcium Ions Tune the Zinc-Sequestering Properties and Antimicrobial Activity of Human S100A12.
Human S100A12 is a host-defense protein expressed and released by neutrophils that contributes to innate immunity. Apo S100A12 is a 21-kDa antiparallel homodimer that harbors two Ca(II)-binding EF-hand domains per subunit and exhibits two His3Asp motifs for chelating transition metal ions at the homodimer interface. In this work, we present results from metal-binding studies and microbiology as...
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ژورنال
عنوان ژورنال: ChemBioChem
سال: 2020
ISSN: 1439-4227,1439-7633
DOI: 10.1002/cbic.201900623